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XF067-68

XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5) . XF067-68 can be usde for the study of WDR5-mediated diseases. (Pink: target protein ligand (HY-141799) ; Blue: E3 ligase ligand (HY-173627) ; Black: linker (HY-Y0966) ; E3 ligase ligand + linker: HY-176517) [1].

Product Specifications

CAS Number

[2407452-79-1]

UNSPSC

12352005

Target

PROTACs; WDR5

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xf067-68.html

Purity

99.56

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(NCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=O)=CC=C4F)=C2

Molecular Formula

C52H59F4N9O7S

Molecular Weight

1030.14

References & Citations

[1]Jian J, et al. Wd40 repeat domain protein 5 (wdr5) degradation/destruction compound and method of use. WO2019246570A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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