5-Aminosalicylic acid-13C6
5-Aminosalicylic acid-13C6 is the 13C labeled 5-Aminosalicylic Acid[1]. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[2][3][4].
Product Specifications
CAS Number
1189709-96-3
Product Name Alternative
Mesalamine-13C6; 5-ASA-13C6; Mesalazine-13C6
UNSPSC
12352005
Target
Endogenous Metabolite; NF-κB; PAK; PPAR
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/5-aminosalicylic-acid-13c6.html
Solubility
10 mM in DMSO
Smiles
OC([13C]1=[13C]([13CH]=[13CH][13C](N)=[13CH]1)O)=O
Molecular Formula
C 13C6H7NO3
Molecular Weight
159.09
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853 (10 Pt A) :2349-60.|[3]Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 2813 (20) :2872-7.|[4]Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov34 (11) :2580-6.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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