5-Aminosalicylic acid-d3

5-Aminosalicylic acid-d3 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3][4].

Product Specifications

CAS Number

[1309283-32-6]

Product Name Alternative

Mesalamine-d3; 5-ASA-d3; Mesalazine-d3

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds; NF-κB; PAK; PPAR

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Cancer

Purity

99.38

Solubility

DMSO : 66.67 mg/mL (ultrasonic; warming)

Smiles

OC(C1=C(C([2H])=C([2H])C(N)=C1[2H])O)=O

Molecular Formula

C7H4D3NO3

Molecular Weight

156.15

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853 (10 Pt A) :2349-60.; Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells i