RS5517

RS5517 is a specific PDZ1-domain antagonist of NHERF1 that prevented its ectopic nuclear entry. RS5517 can be used for the research of colorectal cancer[1][2].

Product Specifications

CAS Number

[2227017-46-9]

UNSPSC

12352005

Target

Na+/H+ Exchanger (NHE)

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rs5517.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(CC2=CC=CC=C2)C3=C(C=CC(Cl)=C3)N1)NC4=CC=C(CO)C=C4

Molecular Formula

C23H19ClN2O2

Molecular Weight

390.86

References & Citations

[1]Saponaro C, et al. β-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy. Oncogene. 2018 Jun;37 (24) :3301-3316. doi: 10.1038/s41388-018-0170-y. Epub 2018 Mar 19.|[2]Capdevielle C, et al. HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53. Neuro Oncol. 2020 Apr 15;22 (4) :550-562.