TNH
TNH (TMP-NVOC linker-Halo) is a dimeric protein chemical inducer that can enter living cells and recruit proteins to cellular structures. TNH senses light signals and acts by recruiting proteins to kinetochores and releasing them from kinetochores (depending on CENP-E (kinesin-7) ) [1].
Product Specifications
CAS Number
[2137895-00-0]
Product Name Alternative
TMP-NVOC linker-Halo
UNSPSC
12352005
Target
Kinesin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tnh.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC(OC)=C(OCCOCCOCCOCCOCCCCCCCl)C=C1[N+]([O-])=O)NCCCOC2=C(OC)C=C(CC3=CN=C(N)N=C3N)C=C2OC
Molecular Formula
C39H57ClN6O13
Molecular Weight
853.36
References & Citations
[1]Huaiying Zhang, et al. Optogenetic control of kinetochore function. Nat Chem Biol. 2017 Oct;13 (10) :1096-1101.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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