SA09-Cu

SA09-Cu is a noncompetitive and potent NDM-1 inhibitor with an IC50 of 9.6 nM. SA09-Cu can convert NDM-1 into an inactive state by oxidizing the Zn (II) -thiolate site of the enzyme and avoids to be reduced by intracellular thiols of bacteria. SA09-Cu exhibits excellent inhibition against a series of clinical NDM-1-producing carbapenem-resistant Enterobacteriaceae (CRE) in restoring the Meropenem (HY-13678) effect, and slows down the development of carbapenem resistance[1].

Product Specifications

CAS Number

[155641-16-0]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/sa09-cu.html

Solubility

10 mM in DMSO

Smiles

OCCN(C)C1=[S-][Cu+2]2(SC(N(C)CCO)=[S-]2)S1

Molecular Formula

C8H16CuN2O2S4

Molecular Weight

364.03

References & Citations

[1]Cheng Chen, et al. Dithiocarbamates combined with copper for revitalizing meropenem efficacy against NDM-1-producing Carbapenem-resistant Enterobacteriaceae. Bioorg Chem. 2022 Jan;118:105474.