YTP-17

YTP-17 is an orally active YAP-TEAD protein-protein interaction inhibitor with an IC50 of 4 nM. YTP-17 shows anti-tumor efficacy[1].

Product Specifications

UNSPSC

12352005

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ytp-17.html

Purity

99.47

Solubility

DMSO : ≥ 100 mg/mL

Smiles

FC1=CC2=C([C@@]([C@@]3=C(C=CC(OCCO)=C3F)C(NC)=O)=C1Cl)C[C@](C4=CC=CC=C4)(CNC)O2

Molecular Formula

C26H25ClF2N2O4

Molecular Weight

502.94

References & Citations

[1]Holger Sellner, et al. Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors. ChemMedChem. 2023 Jun 1;18 (11) :e202300051.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

YAP/TAZ-TEAD

Curated Selection

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