SD-91
SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895) ; Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) [1][2].
Product Specifications
Product Name Alternative
STAT3 degrader-2
UNSPSC
12352005
Target
PROTACs; STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-degrader-2.html
Solubility
10 mM in DMSO
Smiles
Molecular Formula
C59H62N9O13P
Molecular Weight
1136.15
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150251/STAT3-degrader-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150251/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
CAS Number
[2497583-03-4]
Available Sizes
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