SD-91

SD-91 (STAT3 degrader-2), a product of the hydrolysis of SD-36 (HY-129602), is a selective PROTAC-based STAT3 degrader with a Ki of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein (HY-150895) ; Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506) [1][2].

Product Specifications

CAS Number

[2497583-03-4]

Product Name Alternative

STAT3 degrader-2

UNSPSC

12352005

Target

PROTACs; STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stat3-degrader-2.html

Solubility

10 mM in DMSO

Smiles

O=C(N1C[C@@H](C(N2[C@@](CC[C@H]2C(N[C@@H](CCC(N)=O)C(NC(C3=CC=CC=C3)C4=CC=CC=C4)=O)=O)([H])CC1)=O)NC(C5=CC6=CC(C(P(O)(O)=O)=O)=CC=C6N5)=O)CCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7

Molecular Formula

C59H62N9O13P

Molecular Weight

1136.15

References & Citations

[1]Shaomeng Wang, et al. Small molecule degraders of stat3. Patent. WO2020198435A1. |[2]Zhou H, et al. SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. ACS Med Chem Lett. 2021 May 10;12 (6) :996-1004.