BAY-364
BAY-364 (BAY-299N) is an inhibitor of the second bromine domain in TAF1. BAY-364 inhibits the TAF1 of Kasumi-1 cells, CD34+ cells and K562 cells with IC50 values of 1.0 µM, 10.4 µM and 10.0 µM respectively[1].
Product Specifications
CAS Number
2097610-30-3
Product Name Alternative
BAY-299N
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-364.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=CC(N3C(C4=CC=CC5=C4C(C3=O)=CC=C5CCCO)=O)=CC=C2N1C
Molecular Formula
C23H19N3O4
Molecular Weight
401.41
References & Citations
[1]Xu Y, et al. TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Nat Commun. 2019 Oct 29;10 (1) :4925. |[2]Garcia-Carpizo V, et al. Therapeutic potential of TAF1 bromodomains for cancer treatment[J]. bioRxiv, 2018: 394254.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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