ODN MT01
ODN MT01 was designed based on human mitochondrial DNA sequences, which is an inhibitory ODN that promotes osteocyte differentiation. ODN MT01 could promote osteoblast maturation and activation in rats, reduce rat alveolar bone absorption caused by periodontitis, regulate the expression levels of osteogenesis-related factors.
Product Specifications
CAS Number
1817821-77-4
UNSPSC
12352208
Target
Toll-like Receptor (TLR)
Type
Oligonucleotides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/odn-mt-01.html
Solubility
10 mM in DMSO
Smiles
[ODNMT01]
References & Citations
[1]Zhang Q, Qu X, Liang C, et al. Effect of oligonucleotide MT01 delivered by N-isopropylacrylamide modified polyethyleneimine for bone regeneration. Front Bioeng Biotechnol. 2023;11:1204571. |[2]Shen Y, Feng Z, Lin C, et al. An oligodeoxynucleotide that induces differentiation of bone marrow mesenchymal stem cells to osteoblasts in vitro and reduces alveolar bone loss in rats with periodontitis. Int J Mol Sci. 2012;13 (3) :2877-2892. |[3]Zheng Y., Lin C., Hou X., Ma N., Yu W., Xu X., et al. (2017) . Enhancing the osteogenic capacity of MG63 cells through N-isopropylacrylamide-modified polyethylenimine-mediated oligodeoxynucleotide MT01 delivery. RSC Adv. 7, 27121–27127. 10.1039/c6ra27182k
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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