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K34c

K34c is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c can be used in glioblastoma research[1].

Product Specifications

CAS Number

[939769-93-4]

UNSPSC

12352005

Target

Apoptosis; Integrin

Type

Reference compound

Related Pathways

Apoptosis; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/k34c.html

Purity

98.79

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H](CC1=CC=C(OCCCNC2=NC=CC=C2)C=C1)NC(C3=C(C)C=CC=C3C)=O

Molecular Formula

C26H29N3O4

Molecular Weight

447.53

References & Citations

[1]Martinkova E, et al. alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer. 2010 Sep 1;127 (5) :1240-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-150124/K34c-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-150124/K34c-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α5β1

Available Sizes

Curated Selection

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