K34c
K34c is a potent and selective α5β1 integrin antagonist. By inhibiting α5β1 integrin, K34c reduces chemotherapy-induced premature senescence and promotes apoptosis. K34c can be used in glioblastoma research[1].
Product Specifications
CAS Number
[939769-93-4]
UNSPSC
12352005
Target
Apoptosis; Integrin
Type
Reference compound
Related Pathways
Apoptosis; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k34c.html
Purity
98.79
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H](CC1=CC=C(OCCCNC2=NC=CC=C2)C=C1)NC(C3=C(C)C=CC=C3C)=O
Molecular Formula
C26H29N3O4
Molecular Weight
447.53
References & Citations
[1]Martinkova E, et al. alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int J Cancer. 2010 Sep 1;127 (5) :1240-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α5β1
Available Sizes
Curated Selection
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