(±) 14,15-Epoxyeicosatrienoic acid

(±) 14,15-Epoxyeicosatrienoic acid ((±) 14 (15) -EET) is the Cytochrome P450 metabolite of arachidonic acid. While CYP3A4 may be involved in breast cancer cell growth, (±) 14,15-Epoxyeicosatrienoic acid may promote mitosis and anchorage-dependent cloning through STAT3 affected by CYP3A4. (±) 14,15-Epoxyeicosatrienoic acid exhibits STAT3-dependent cell growth promotion and may also participate in the autocrine/paracrine pathway that drives cell growth[1][2].

Product Specifications

CAS Number

[197508-62-6]

Product Name Alternative

(±) 14 (15) -EET

UNSPSC

12352005

Hazard Statement

H225

Target

Cytochrome P450; Mitosis

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/racemic-14-15-epoxyeicosatrienoic-acid.html

Concentration

312.04 μM * 500 μL in Ethanol

Purity

99.9

Solubility

10 mM in DMSO

Smiles

OC(CCC/C=C\C/C=C\C/C=C\CC1C(O1)CCCCC)=O

Molecular Formula

C20H32O3

Molecular Weight

320.47

Precautions

H225

References & Citations

[1]Mitra R, et al. CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±) -14,15-epoxyeicosatrienoic acid (EET) . J Biol Chem. 2011 May 20;286 (20) :17543-59.|[2]Zhang DX, et al. Acetylcholine-induced relaxation and hyperpolarization in small bovine adrenal cortical arteries: role of cytochrome P450 metabolites. Endocrinology. 2004 Oct;145 (10) :4532-9.