PRMT5-IN-21
PRMT5-IN-21 (compound 1) is a potent cyclonucleoside PRMT5 inhibitor[1].
Product Specifications
CAS Number
2922673-38-7
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prmt5-in-21.html
Solubility
10 mM in DMSO
Smiles
FC1=C(F)C=CC([C@@H]2[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C(N=CN=C5N)=C5N=C4NCC2)O3)=C1
Molecular Formula
C18H18F2N6O3
Molecular Weight
404.37
References & Citations
[1]Kawamura S, et al. Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity. Bioorg Med Chem. 2022 Jul 15;66:116820.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT5
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