OX01914

OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC50 of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD) [1].

Product Specifications

CAS Number

[49676-35-9]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ox01914.html

Solubility

10 mM in DMSO

Smiles

O=C(NN)C1=NC(C2=CC=CC=C2)=CC(C3=CC=CC=C3)=N1

Molecular Formula

C17H14N4O

Molecular Weight

290.32

References & Citations

[1]Vuorinen A, et al. Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy. Eur J Med Chem. 2021 Aug 5;220:113431.