Utrophin modulator 1

Utrophin modulator 1 is a potent utrophin modulator (upregulates utrophin protein levels), with an EC50 of 0.11 μM. Utrophin modulator 1 can be used in study of duchenne muscular dystrophy (DMD) [1].

Product Specifications

CAS Number

[3068935-32-7]

UNSPSC

12352005

Target

Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/utrophin-modulator-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NN)C1=NC(N2CC(C=CC=C3)=C3C2)=CC(C4=CC(N=CC=C5)=C5C=C4)=N1

Molecular Formula

C22H18N6O

Molecular Weight

382.42

References & Citations

[1]Chatzopoulou M, et al. Structure-activity relationships of 2-pyrimidinecarbohydrazides as utrophin modulators for the potential treatment of Duchenne muscular dystrophy. Bioorg Med Chem. 2022 Sep 1;69:116812.