Antimalarial agent 16

Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM) [1].

Product Specifications

CAS Number

[2773408-33-4]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/antimalarial-agent-16.html

Solubility

10 mM in DMSO

Smiles

CCCCC1=CC(OC2=C1C(O[C@H](C)C(N3CC4=C(C5=C(N4)C=CC=C5)C[C@H]3C(OC)=O)=O)=CC(C)=C2)=O

Molecular Formula

C30H32N2O6

Molecular Weight

516.58

References & Citations

[1]Nobuo Cho, et al. New antimalarials identified by a cell-based phenotypic approach: Structure-activity relationships of 2,3,4,9-tetrahydro-1H-β-carboline derivatives possessing a 2- ((coumarin-5-yl) oxy) alkanoyl moiety. Bioorg Med Chem. 2022 Jul 15;66:116830.