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Antibacterial agent 116

Antibacterial agent 116 is a benzophenone-containing salicylanilide compound. Antibacterial agent 116 has potent antibacterial activity by inhibiting the peptidoglycan formation. Antibacterial agent 116 is used as a photoaffinity probe to label Acinetobacter baumannii penicillin-binding protein (PBP1b), block the propagation pathway to disrupt the growth of peptidoglycan chain[1].

Product Specifications

CAS Number

99330-28-6

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Bacterial; Penicillin-binding protein (PBP)

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antibacterial-agent-116.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C(I)=CC(I)=C1)O)NC2=CC(C(C3=CC=C(C=C3)Cl)=O)=CC=C2OC4=CC=C(C=C4)Cl

Molecular Formula

C26H15Cl2I2NO4

Molecular Weight

730.12

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Chuang HC, et al. Photoaffinity labeling of benzophenone-containing salicylanilide compounds to give an insight into the mechanism in disrupting peptidoglycan formation. Bioorg Med Chem. 2022 Aug 1;67:116819.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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