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NVP-BBD130

NVP-BBD130 is a potent, stable, ATP-competitive and orally active dual PI3K and mTOR inhibitor[1]. NVP-BBD130 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[853910-61-9]

UNSPSC

12352005

Target

MTOR; PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nvp-bbd130.html

Solubility

10 mM in DMSO

Smiles

N#CC(C)(C)C1=CC=C(N2C(N(C)C3=CN=C4C=CC(C#CC5=CC=CN=C5)=CC4=C32)=O)C=C1

Molecular Formula

C28H21N5O

Molecular Weight

443.50

References & Citations

[1]Marone R, et al. Targeting melanoma with dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitors. Mol Cancer Res. 2009 Apr;7 (4) :601-13.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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