INOs-IN-3
INOs-IN-3 (Compound 2d) is an orally active nitric oxide synthase (iNOS) inhibitor (IC50=3.342 μM) . iNOs-IN-3 shows anti-inflammatory activity and can be used in LPS-induced acute lung injury (ALI) research[1].
Product Specifications
CAS Number
[2241674-94-0]
UNSPSC
12352005
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/inos-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=CC=CC(OS(=O)(C3=CC=CC4=C(N(C)C)C=CC=C43)=O)=C2N1CCC5=CC=CC=C5
Molecular Formula
C27H24N2O5S
Molecular Weight
488.55
References & Citations
[1]Li Tang, et al. Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI) . Bioorg Med Chem. 2020 Nov 1;28 (21) :115733.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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