Gamma-secretase modulator 5
Gamma-secretase modulator 5 (compound 22d) is a brain-penetrant gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 60 nM. gamma-secretase modulator 5 can be used in the study of Alzheimer's disease[1].
Product Specifications
CAS Number
1353570-53-2
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gamma-secretase-modulator-5.html
Solubility
10 mM in DMSO
Smiles
CC1=CN(C2=CC=C(C3=CSC(NC4=C5C(CCCC5)=NN4CC)=N3)N=C2OC)C=N1
Molecular Formula
C22H25N7OS
Molecular Weight
435.55
References & Citations
[1]Kevin D Rynearson, et al. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 Nov 15;28 (22) :115734.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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