γ-Secretase modulator 13
γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease[1].
Product Specifications
CAS Number
[1353570-40-7]
UNSPSC
12352005
Target
Amyloid-β
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/γ-secretase-modulator-13.html
Solubility
10 mM in DMSO
Smiles
FC1=C(N2C=NC(C)=C2)C=CC(C3=CSC(NC4=C5C(CCCC5)=NN4CC)=N3)=C1
Molecular Formula
C22H23FN6S
Molecular Weight
422.52
References & Citations
[1]Kevin D Rynearson, et al. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 Nov 15;28 (22) :115734.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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