γ-Secretase modulator 13

γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC50 value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease[1].

Product Specifications

CAS Number

[1353570-40-7]

UNSPSC

12352005

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/γ-secretase-modulator-13.html

Solubility

10 mM in DMSO

Smiles

FC1=C(N2C=NC(C)=C2)C=CC(C3=CSC(NC4=C5C(CCCC5)=NN4CC)=N3)=C1

Molecular Formula

C22H23FN6S

Molecular Weight

422.52

References & Citations

[1]Kevin D Rynearson, et al. Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 Nov 15;28 (22) :115734.