Nek2-IN-6
Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor[1].
Product Specifications
CAS Number
2410376-96-2
UNSPSC
12352005
Target
NEKs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nek2-in-6.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CC=CC=C1C(F)(F)F)OC2=C(SC(C3=CN=C4C=C(C=CN34)C5=CN(N=C5)CC6CN(C6)C(OC(C)(C)C)=O)=C2)C(N)=O
Molecular Formula
C33H33F3N6O4S
Molecular Weight
666.71
References & Citations
[1]Wang H, et al. Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a] pyridine derivatives as Nek2 inhibitors. Bioorg Med Chem. 2020 Dec 1;28 (23) :115775.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NEK2
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