MDTF (free acid)
MDTF free acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
2102021-49-6
UNSPSC
12352203
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mdtf-free-acid.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1CO[C@H](OC1)CN2C(C=CC2=O)=O)OC3=C(C(F)=C(C(F)=C3F)S(=O)(O)=O)F
Molecular Formula
C16H11F4NO9S
Molecular Weight
469.32
References & Citations
[1]Dovgan I, et, al. 2- (Maleimidomethyl) -1,3-Dioxanes (MD) : a Serum-Stable Self-hydrolysable Hydrophilic Alternative to Classical Maleimide Conjugation. Sci Rep. 2016 Aug 9;6:30835.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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