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Multi-kinase-IN-3

Multi-kinase-IN-3 (compound 2) is a potent angiokinase inhibitor. Multi-kinase-IN-3 shows inhibition activity against VEGFR-2 and PDGFRβ, with IC50 values of 58.3 and 55 nM, respectively[1].

Product Specifications

CAS Number

2091950-43-3

UNSPSC

12352005

Target

PDGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/multi-kinase-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N4C=CC=C4CN5CCN(C)CC5)C=C3)/C6=CC=CC=C6)OC

Molecular Formula

C33H33N5O3

Molecular Weight

547.65

References & Citations

[1]Qin M, et al. Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity. Bioorg Med Chem. 2020 Jun 1;28 (11) :115486.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDGFRβ; VEGFR2/KDR/Flk-1

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