(4aS,8aR) -NPD-001

(4aS,8aR) -NPD-001 is a potent and allosteric inhibitor of DNMT3A. (4aS,8aR) -NPD-001 inhibits DNMT3A activity by disrupting protein-protein interactions. (4aS,8aR) -NPD-001 induces apoptosis of acute myeloid leukemia (AML) cell lines. (4aS,8aR) -NPD-001 induces differentiation of distinct AML cell lines including cells with mutated DNMT3A R882[1].

Product Specifications

CAS Number

[2366272-43-5]

UNSPSC

12352005

Target

Apoptosis; DNA Methyltransferase

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dnmt3a-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C2CCCCCC2)N=C(C3=CC=C(OC)C(OCCCCOC4=CC=C(C5=NN=NN5)C=C4)=C3)[C@@]6([H])CC=CC[C@@]16[H]

Molecular Formula

C33H40N6O4

Molecular Weight

584.71

References & Citations

[1]Sandoval JE, et al. First-in-Class Allosteric Inhibitors of DNMT3A Disrupt Protein-Protein Interactions and Induce Acute Myeloid Leukemia Cell Differentiation. J Med Chem. 2022 Jul 22.