GRK5-IN-4

GRK5-IN-4 (Compound 16d, CCG-265328) is a potent and and selective covalent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 1.1 μM. GRK5-IN-4 shows 90-fold selectivity over GRK2. GRK5-IN-4 can be used for heart failure research[1]. GRK5-IN-4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2410794-89-5]

Product Name Alternative

CCG-265328

UNSPSC

12352005

Target

G Protein-coupled Receptor Kinase (GRK)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/grk5-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CC=C(C(OC)=C1)NC2=NC(NC3=C(C(NC)=O)C=CC=C3)=C4C=CNC4=N2)C#CC

Molecular Formula

C26H25N7O3

Molecular Weight

483.52

References & Citations

[1]Rowlands RA, et al. Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. ACS Med Chem Lett. 2019 Nov 12;10 (12) :1628-1634.