C-Met/HDAC-IN-3
C-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase[1].
Product Specifications
CAS Number
[2439175-23-0]
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-hdac-in-3.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2N=CC=C(C2=C1)OC3=CC=C(C=C3)NC(C4CCN(C4=O)C5=CC=C(C=C5)F)=O)OCCCCCCC(NO)=O
Molecular Formula
C34H35FN4O7
Molecular Weight
630.66
References & Citations
[1]Hu H, et al. Discovery of novel dual c-Met/HDAC inhibitors as a promising strategy for cancer therapy. Bioorg Chem. 2020 Aug;101:103970.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1
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