Antimycobacterial agent-5
Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide targeting mycobacterial electron transport chain (ETC) airway CIII2CIV2 supercomplexes. The IC50 value of Antimycobacterial agent-5 against Mycobacterium smegmatisCIII2CIV2 is 441 nM[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis; Bacterial; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antimycobacterial-agent-5.html
Solubility
10 mM in DMSO
Smiles
ClC(C=C1)=CN2C1=NC(CC)=C2C(NC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=O
Molecular Formula
C25H34ClN3O
Molecular Weight
428.01
References & Citations
[1]Rana Abdelaziz, et al. Imidazopyridine Amides: Synthesis, Mycobacterium smegmatis CIII2CIV2 Supercomplex Binding, and In Vitro Antimycobacterial Activity. ACS Omega. 2023 May 18;8 (21) :19081-19098.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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