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Pim-1 kinase inhibitor 6

Selected Variant

HY-149996

Size: 1 Each

Pim-1 kinase inhibitor 6 (Compound 4d) is a potent Pim-1 kinase inhibitor with IC50 value of 0.46 μM, and has significant cytotoxic effect on cancer cells[1].

Product Specifications

CAS Number

2928606-69-1

UNSPSC

12352005

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pim-1-kinase-inhibitor-6.html

Solubility

10 mM in DMSO

Smiles

ClC(C(C1=CC(C2=CC=C(Br)C=C2)=NC(Cl)=C1C#N)=C3)=NC4=C3C=CC=C4

Molecular Formula

C21H10BrCl2N3

Molecular Weight

455.13

References & Citations

[1]Basem Mansour, et al. Cyanopyridinone- and Cyanopyridine-Based Cancer Cell Pim-1 Inhibitors: Design, Synthesis, Radiolabeling, Biodistribution, and Molecular Modeling Simulation. ACS Omega. 2023 May 24;8 (22) :19351-19366.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Price

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