MAO-B-IN-21
MAO-B-IN-21 is an excellent MAO-B inhibitor with antioxidant activity and anti-Aβ aggregation activity. MAO-B-IN-21 also exhibits metal-ion chelating ability, anti-neuroinflammation (NO, TNF-α), neuroprotective activity and BBB permeability. MAO-B-IN-21 significantly improves the memory and cognitive impairment in Aβ1-42 induced Alzheimer's disease mice model[1].
Product Specifications
CAS Number
2956426-18-7
UNSPSC
12352005
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mao-b-in-21.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCC1OC(C2=CC(N3N=C(CC3=O)C4=CC(Cl)=CC=C4O)=CC=C21)=O
Molecular Formula
C24H25ClN2O4
Molecular Weight
440.92
References & Citations
[1]Cong S, et al. Discovery of novel 5- (2-hydroxyphenyl) -2-phthalide-3 (3H) -pyrazolones as balanced multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115216.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAO-B
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