Pim-1 kinase inhibitor 4
Pim-1 kinase inhibitor 4 (Compound 10f) is a Pim-1 kinase inhibitor (IC50: 17.01 nM) . Pim-1 kinase inhibitor 4 also has antioxidant activity and inhibits DPPH. Pim-1 kinase inhibitor 4 induces apoptosis in PC-3 cell, and inhibits PC-3 cell growth with an IC50 of 16 nM. Pim-1 kinase inhibitor 4 can be used for research of prostate cancer[1].
Product Specifications
CAS Number
3026670-71-0
UNSPSC
12352005
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim-1-kinase-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(C2=NN=C(O2)C3=CC=NC(C4=CC=CC=C4)=C3)=CC=C1
Molecular Formula
C19H12ClN3O
Molecular Weight
333.77
References & Citations
[1]Castanet AS, et al. Discovery of PIM-1 kinase inhibitors based on the 2,5-disubstituted 1,3,4-oxadiazole scaffold against prostate cancer: Design, synthesis, in vitro and in vivo cytotoxicity investigation. Eur J Med Chem. 2023 Mar 15;250:115220.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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