AMPA receptor modulator-4

AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs) . AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice[1].

Product Specifications

CAS Number

[2917551-59-6]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ampa-receptor-modulator-4.html

Solubility

10 mM in DMSO

Smiles

O=S1(C2=CC(Cl)=CC=C2N(C3CC3)CN1CF)=O

Molecular Formula

C11H12ClFN2O2S

Molecular Weight

290.74

References & Citations

[1]Eric Goffin, et al. New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro) methyl groups at the 2-position of the thiadiazine ring. Eur J Med Chem. 2023 Mar 15;250:115221.