TRK-IN-23
TRK-IN-23 (compound 24b) is a potent and orally active TRK inhibitor with IC50 values of 0.5 nM, 9 nM, 14 nM, 4.4 nM, and 4.8 nM against TRKA, TRKC, TRKAG595R, TRKAF589L, and TRKAG667C, respectively. TRK-IN-23 indues apoptosis of Ba/F3-TRKAG595Rand Ba/F3-TRKAG667C cells[1].
Product Specifications
CAS Number
2924344-29-4
UNSPSC
12352005
Target
Apoptosis; Trk Receptor
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-23.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1CNC2=CC3=C(NC(/C3=C\C4=CN=CN4)=O)C=C2)F
Molecular Formula
C20H17FN4O2
Molecular Weight
364.37
References & Citations
[1]Qiaohua Qin, et al. Design, synthesis and biological evaluation of novel indolin-2-one derivatives as potent second-generation TRKs inhibitors. Eur J Med Chem. 2023 May 5;253:115291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkC
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K7128003 1.0 µg DNA
Cacna1f sgRNA CRISPR Lentivector (Rat) (Target 2)
Sign In for Pricing
View Details