Antileishmanial agent-16

Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC50 = 0.59 µM) and anti-Leishmania major amastigotes activity (IC50 = 0.81 µM) . Antileishmanial agent-16 has good safety to mammalian cells (VERO cells) [1].

Product Specifications

CAS Number

[2934738-41-5]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antileishmanial-agent-16.html

Solubility

10 mM in DMSO

Smiles

CCCCOC1=CC2=C(C=C(C(O2)=O)C(NCCCCCCN3C=C(N=N3)CN4CCCC4)=O)C=C1

Molecular Formula

C27H37N5O4

Molecular Weight

495.61

References & Citations

[1]Hassan NW, et al. Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies. Eur J Med Chem. 2023 May 5;253:115333.