Analgesic agent-2

Analgesic agent-2 is a selective and orally active NaV1.8 Channel inhibitor, with an IC50 of 50.18 nM in HEK293 cells stably expressing human NaV1.8 channel. Analgesic agent-2 has analgesic activity[1].

Product Specifications

CAS Number

[2983892-65-3]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/analgesic-agent-2.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C=C(C(N2CCCC(F)(CC2)F)=N1)C(NC3=CC4=C(CNC4=O)C=C3)=O)Cl

Molecular Formula

C21H21ClF2N4O2

Molecular Weight

434.87

References & Citations

[1]Qin H, et al. Discovery of selective NaV1.8 inhibitors based on 5-chloro-2- (4,4-difluoroazepan-1-yl) -6-methyl nicotinamide scaffold for the treatment of pain. Eur J Med Chem. 2023 Jun 5;254:115371.