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PAP-IN-1

PAP-IN-1 (compound 28) is an inhibitor of purple acid phosphatases (PAPs), a ubiquitous binuclear metallohydrolase. PAP-IN-1 inhibits mammalian PAP with Ki value of 168 nM. PAP-IN-1 targets to pig PAP with Kic value of 0.17 μM. PAP inhibitors can be used for research of anti-osteoporotic drugs[1].

Product Specifications

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/pap-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(CCCCCCCCCCCCCCCCC)NC(P(O)(O)=O)C1=CC=CC=C1

Molecular Formula

C25H44NO4P

Molecular Weight

453.59

References & Citations

[1]Feder D, et al. Optimization of an α-aminonaphthylmethylphosphonic acid inhibitor of purple acid phosphatase using rational structure-based design approaches. Eur J Med Chem. 2023 Jun 5;254:115383.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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