HNTS1R agonist-1
HNTS1R agonist-1 (Compound 10) is a BBB permeable hNTS1R full agonist (Ki: 6.9 nM) . hNTS1R agonist-1 increases motor function and memory in a mouse model of Parkinson's disease (PD) . hNTS1R agonist-1 is a Neurotensin (8-13) analog and is a neuroprotective agent[1].
Product Specifications
UNSPSC
12352209
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/hnts1r-agonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(CCC1)C([C@H](CCONC(N)=N)NC([C@@H](N)CCCCN)=O)=O)N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)[C@H](CC)C)=O)CC2=CC=C(O)C=C2
Molecular Formula
C37H62N10O9
Molecular Weight
790.95
References & Citations
[1]Kühl T, et al. Neurotensin (8-13) analogs as dual NTS1 and NTS2 receptor ligands with enhanced effects on a mouse model of Parkinson's disease. Eur J Med Chem. 2023 Jun 5;254:115386.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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