OICR-8268
OICR-8268 is a reversible DCAF1 ligand that binds to the DCAF1 WDR domain with a Kd of 38 nM. OICR-8268 can enable the development of DCAF1-based PROTACs[1].
Product Specifications
CAS Number
[3000549-26-5]
UNSPSC
12352005
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oicr-8268.html
Purity
99.23
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CNN=C1C2=CC=C(Cl)C=C2F)N[C@H](C3=CC=C(F)C(Cl)=C3)CC(N)=O
Molecular Formula
C19H14Cl2F2N4O2
Molecular Weight
439.24
References & Citations
[1]Alice Shi Ming Li, et al. Discovery of Nanomolar DCAF1 Small Molecule Ligands. J Med Chem. 2023 Apr 13;66 (7) :5041-5060.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Curated Selection
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