NNRT-IN-1
NNRT-IN-1 (compound 8r) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor featuring significantly anti-resistance efficacy. NNRT-IN-1 inhibits the wild-type HIV-1 and five mutant strains with EC50s in the nanomolar range. NNRT-IN-1 displays favorable pharmacokinetic properties[1].
Product Specifications
CAS Number
2925364-09-4
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nnrt-in-1.html
Solubility
10 mM in DMSO
Smiles
CONC(C1=C(N=C(N=C1)NC2=CC=C(C=C2)C#N)OC3=C(C=C(C=C3C)C4=CC=C(C=C4)C#N)C)=O
Molecular Formula
C28H22N6O3
Molecular Weight
490.51
References & Citations
[1]Sang YL, et, al. Fragment Hopping-Based Design of Novel Biphenyl-DAPY Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Improved Anti-Resistance Efficacy. J Med Chem. 2023 Apr 13;66 (7) :4755-4767.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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