A2AR-antagonist-1
A2AR-antagonist-1 (compound 38) is an orally active adenosine A2A receptor (A2AR) antagonist (IC50=29 nM) . A2AR-antagonist-1 exhibits anti-tumor activity and mouse liver microsomal metabolic stability (t1/2=86.1 min) . A2AR-antagonist-1 is also a T cells activator, via inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and enhancing effector molecules (GZMB, IFNG, and IL-2) [1].
Product Specifications
CAS Number
2922920-71-4
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a2ar-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CC1=CC=CC(C(O)(C)C)=C1)C=C2)C=C2C3=NC(N)=NC(C4=C(C)C(C#N)=CC=C4)=C3
Molecular Formula
C27H25N5O2
Molecular Weight
451.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A2A receptor (A2AR)
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
![Rabbit Polyclonal PRR5L Antibody [Alexa Fluor 488]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
Rabbit Polyclonal PRR5L Antibody [Alexa Fluor 488]
Epstein Barr Virus, Capsid Antigen p160 (EBV, Human Herpes virus 4, HHV4) (MaxLight 490) discontinued
EGFR, Human (ΔE746-A750, T790M, C797S, L858R, Active, sf9, His-GST)
Wdr83 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)