VDR agonist 2
VDR agonist 2 (compound 16i) is a VDR (vitamin D receptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC) . VDR agonist 2 has significant anti-hepatic fibrosis effects both in vitro and in vivo[1].
Product Specifications
CAS Number
3052323-55-1
UNSPSC
12352005
Target
VD/VDR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vdr-agonist-2.html
Solubility
10 mM in DMSO
Smiles
FC(F)(CCCOC1=CC=C(/C=C/C2=CC=C(C(CO)=C2)CO)C=C1)F
Molecular Formula
C20H21F3O3
Molecular Weight
366.37
References & Citations
[1]Xing K, et al. Design, synthesis and anti-hepatic fibrosis activity of novel diphenyl vitamin D receptor agonists. Eur J Med Chem. 2023 Oct 5;258:115596.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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