VDR agonist 2

VDR agonist 2 (compound 16i) is a VDR (vitamin D receptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC) . VDR agonist 2 has significant anti-hepatic fibrosis effects both in vitro and in vivo[1].

Product Specifications

CAS Number

3052323-55-1

UNSPSC

12352005

Target

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/vdr-agonist-2.html

Solubility

10 mM in DMSO

Smiles

FC(F)(CCCOC1=CC=C(/C=C/C2=CC=C(C(CO)=C2)CO)C=C1)F

Molecular Formula

C20H21F3O3

Molecular Weight

366.37

References & Citations

[1]Xing K, et al. Design, synthesis and anti-hepatic fibrosis activity of novel diphenyl vitamin D receptor agonists. Eur J Med Chem. 2023 Oct 5;258:115596.