HSP90-IN-23
HSP90-IN-23 (Comp 12-1) is an inhibitor of heat shock protein 90 (HSP90) with an IC50 of 9 nM. HSP90-IN-23 induces apoptosis of tumor cells and arrests the tumor cell cycle in G0/G1 phase. HSP90-IN-23 can be used for cancer research[1].
Product Specifications
CAS Number
[2944100-30-3]
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsp90-in-23.html
Purity
98.25
Solubility
10 mM in DMSO
Smiles
OC1=CC(O)=C(C=C1C(C)C)C2=C(C(C(NCC)=O)=NO2)C3=CC=C(C=C3)S(=O)(C)=O
Molecular Formula
C22H24N2O6S
Molecular Weight
444.50
References & Citations
[1]Fang X, et.al. Development of VER-50589 analogs as novel Hsp90 inhibitors. Bioorg Med Chem Lett. 2023 Jul 15;91:129375.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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