Quorum sensing-IN-2
Quorum sensing-IN-2 (compound 23e) is a quorum sensing inhibitor, which can reduce the pathogenicity of bacteria without affecting bacterial growth. Quorum sensing-IN-2 inhibits bacterial infections with little hemolytic activity. Quorum sensing-IN-2 shows synergistic effect with Ciprofloxacin (HY-B0356) in the bacteremia model infected with P. aeruginosa PAO1[1].
Product Specifications
CAS Number
[2925926-80-1]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/quorum-sensing-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C(CNC(C1=CC=C(C=C1)F)=O)=C2C3=CC=C(C=C3)F)OC2=C
Molecular Formula
C19H13F2NO3
Molecular Weight
341.31
References & Citations
[1]Zhang P, et al. Design and Synthesis of 4-Fluorophenyl-5-methylene-2 (5H) -furanone Derivatives as Potent Quorum Sensing Inhibitors. J Med Chem. 2023 Jul 13;66 (13) :8441-8463.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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