HDHODH-IN-12
HDHODH-IN-12 is a potent DHODH inhibitor with an IC50 value of 0.421 μM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdhodh-in-12.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CNC2=C1C=C(NC3=CC=C([N+]([O-])=O)C=C3)C=C2)NC4=CC=CC(C(F)(F)F)=C4
Molecular Formula
C22H15F3N4O3
Molecular Weight
440.37
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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