PROTAC CDK9 degrader-8
PROTAC CDK9 degrader-8 (compound 21) is a potent PROTAC CDK9 degrader with an IC50 value of 0.01 μM. PROTAC CDK9 degrader-8 can be used in research of cancer[1].
Product Specifications
CAS Number
2994191-89-6
UNSPSC
12352005
Target
CDK; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-cdk9-degrader-8.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NNC=C1NC(C2=C(Cl)C=CC=C2Cl)=O)NC3CCN(CCCCCCCCCCC4=CN(CCCOC5=CC=CC(C(N6C(CC7)C(NC7=O)=O)=O)=C5C6=O)N=N4)CC3
Molecular Formula
C44H52Cl2N10O7
Molecular Weight
903.85
References & Citations
[1]Oluwatosin RA, et, al. Examination of the Impact of Triazole Position within Linkers on Solubility and Lipophilicity of a CDK9 Degrader Series. ACS Med. Chem. Lett. 2023, 14 (7) :936-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9
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