TPE-1p

TPE-1p is a cascade-activated AIEgen-peptide probe. TPE-1p self-assembles in aqueous solution to exhibit bright fluorescence in response to alkaline phosphatase (ALP) and ChT-L. TPE-1p can be utilized to noninvasively assess the inhibition efficiency of a ChT-L inhibitor in cells[1].

Product Specifications

UNSPSC

12171500

Target

Fluorescent Dye; Phosphatase

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tpe-1p.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CC(O)=O)=O)=O)CC2=CC=C(OP(O)(O)=O)C=C2)C3=CC=C(/C(C4=CC=CC=C4)=C(C5=CC=CC=C5)/C6=CC=CC=C6)C=C3

Molecular Formula

C53H49N4O15P

Molecular Weight

1012.95

References & Citations

[1]Jiao Q, et al. Cascade-Activated AIEgen-Peptide Probe for Noninvasively Monitoring Chymotrypsin-like Activity of Proteasomes in Cancer Cells. Anal Chem. 2023 Jun 13;95 (23) :9097-9106.