Mip-IN-1
Mip-IN-1 (S, S-28i) is a new rapamycin-derived macrophage infectivity potentiator (Mip) inhibitor. Mip-IN-1 displays strong anti-enzymatic activity against the Mip proteins of Neisseria meningitidis and Neisseria gonorrhoeae and substantially improved the ability of macrophages to kill the bacteria[1].
Product Specifications
CAS Number
2984599-57-5
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mip-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC([C@H]1N(CCCC1)S(=O)(CC2=CC=CC=C2)=O)=O)C3=CC=C(C=C3)F)NCC4=CN=CC=C4
Molecular Formula
C27H29FN4O4S
Molecular Weight
524.61
References & Citations
[1]Scheuplein NJ, et al. Analysis of Structure-Activity Relationships of Novel Inhibitors of the Macrophage Infectivity Potentiator (Mip) Proteins of Neisseria meningitidis, Neisseria gonorrhoeae, and Burkholderia pseudomallei. J Med Chem. 2023 Jul 13;66 (13) :8876-8895.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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